Anticancer Tc9 cells
نویسندگان
چکیده
IL-9-producing cytotoxic T (Tc9) cells represent a unique CD8+ T-cell subset. These long-lived immune cells possess the capacity to acquire effector function and home to tumor tissues after adoptive transfer. IL-9 is indispensable for Tc9-mediated superior antitumor response. These findings are highly significant and crucial to achieve advances in T cell-based adoptive therapies.
منابع مشابه
Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers.
Because cytokine-priming signals direct CD8(+) T cells to acquire unique profiles that affect their ability to mediate specific immune responses, here we generated IL-9-skewed CD8(+) T (Tc9) cells by priming with Th9-polarized condition. Compared with type-I CD8(+) cytotoxic T (Tc1) cells, Tc9 secreted different cytokines and were less cytolytic in vitro but surprisingly elicited greater antitu...
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2014